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目的:研究左旋千金藤立定(SPD)对溴隐亭(Bro)诱导的促乳素(PRL)水平低下的对抗作用。方法:哺乳期母鼠sc Bro 0.5mg·kg~(-1)·d~(-1),PRL显著降低,乳腺组织发育不良,而且仔鼠体重增长缓慢。用放免法测定母鼠PRL,检查乳腺发育状况,评价SPD的对抗作用。结果:SPD30及100mg·kg~(-1)·d~(-1)ip,能够显著对抗Bro诱导的母鼠PRL降低,分娩后d15PRL为11±4及23±6μg·L~(-1)(生理盐水为7±2),而且乳腺组织发育正常,仔鼠在出生后d11—15内迅速生长发育。结论:SPD能阻断大鼠脑垂体前叶的D_2受体,是一个D_2受体的拮抗剂。
OBJECTIVE: To study the antagonistic effect of L-Metoclopidine (SPD) on the low level of prolactin (PRL) induced by bromocriptine. Methods: The sc Bro 0.5 mg · kg -1 d -1 during lactation, the PRL decreased significantly, the mammary gland developed poorly, and the body weight of the offspring increased slowly. PRA was measured by radioimmunoassay, the development of mammary gland was examined, and the antagonistic effect of SPD was evaluated. Results: SPD30 and 100 mg · kg -1 d -1 ip could significantly reduce the PRL of bro-induced maternal rats. The d15PRL after delivery was 11 ± 4 and 23 ± 6 μg · L -1, (Saline 7 ± 2), and normal mammary gland tissue development, pups d11-15 after birth rapid growth and development. Conclusion: SPD can block D_2 receptor in the anterior pituitary of rats and is an antagonist of D_2 receptor.