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目的:探讨肥胖型多囊卵巢综合征患者性激素结合球蛋白与糖、脂代谢的相关性。方法:收集温州市中西医结合医院2016年4月至2019年4月收治的肥胖型多囊卵巢综合征的患者114例。根据性激素结合球蛋白水平将患者分为两组，其中低水平组为66例，正常组为48例。测定两组患者的血糖、血脂及性激素水平，并对结果进行分析。结果:低水平组胆固醇[(2.32±0.97)mmol/L]、甘油三酯[(6.45±1.25)mmol/L]、低密度脂蛋白胆固醇[(3.57±1.01)mmol/L]、载脂蛋白B[(0.93±0.32)g/L]均高于正常组[(1.87±0.89)mmol/L、(4.88±0.94)mmol/L、(3.12±0.88)mmol/L和(0.76±0.17)g/L](n t＝2.477～7.322，均n P<0.05)，低水平组载脂蛋白A[(1.22±0.34)g/L]低于正常组[(1.58±0.47)g/L)](n t＝-4.748，n P0.05)。低水平组空腹血糖[(5.53±1.45)mmol/L]、糖化血红蛋白[(6.42±0.79)%]和空腹胰岛素[(18.71±5.46)mU/L]均高于正常组[(5.09±0.76)mmol/L、(6.01±0.92)%和(15.49±4.98)mU/L](n t＝2.136～3.225，均n P0.05)。低水平组胰岛素抵抗的发生率[54.55%(36/66)]高于正常组[35.42%(17/48)](χn 2＝4.088，n P<0.05)。低水平组睾酮[(61.45±21.44)μg/L]高于正常组[(50.39±22.31)μg/L](n t＝2.673，n P0.05)。n 结论:低性激素结合球蛋白患者更易发生高血糖、高血脂，性激素结合球蛋白水平降低可能是肥胖型多囊卵巢综合征患者出现糖、脂紊乱的危险因素。“,”Objective:To explore the relationship between sex hormone binding globulin and glycolipid metabolism in patients with obese polycystic ovary syndrome.Methods:From April 2016 to April 2019, 114 patients with obese polycystic ovary syndrome in the Integrated Chinese and Western Medicine Hospital of Wenzhou were selected and divided into two groups according to the level of sex hormone binding globulin, including 66 cases in the low level group and 48 cases in the normal group.The blood glucose, blood lipid and sex hormone levels of the two groups were measured and the results were analyzed.Results:The levels of TC, TG, LDL-C and ApoB in the low level group[(2.32±0.97)mmol/L, (6.45±1.25)mmol/L, (3.57±1.01)mmol/L, (0.93±0.32)g/L] were significantly higher than those in the normal group[(1.87±0.89)mmol/L, (4.88±0.94)mmol/L, (3.12±0.88)mmol/L, (0.76±0.17)g/L](n t=2.477-7.322, all n P<0.05). The level of ApoA in the low level group[(1.22±0.34)g/L] was significantly lower than that in the normal group[(1.58±0.47)g/L](n t=-4.748, n P0.05]. The levels of FPG, HbA1C and FINS in the low level group[(5.53±1.45)mmol/L, (6.42±0.79)% and (18.71±5.46)mU/L] were significantly higher than those in the normal group[(5.09±0.76)mmol/L, (6.01±0.92)% and (15.49±4.98)mU/L](n t=2.136-3.225, all n P0.05). The incidence of insulin resistance in the low level group[54.55%(36/66)] was significantly higher than that in the normal group[35.42%(17/48)](χn 2=4.088, n P<0.05). The level of T in the low level group[(61.45±21.44)ng/mL] was significantly higher than that in the normal group[(50.39±22.31)ng/mL](n t=2.673, n P0.05).n Conclusion:The patients with low levels of sex hormone binding globulin are more likely to suffer from hyperglycemia and hyperlipidemia, and low levels of sex hormone binding globulin may be a risk factor for obese polycystic ovary syndrome.