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DNA损伤未及时有效地修复可导致基因组不稳定 ,增加肿瘤发生率。 DSB是基因突变、染色体断裂的主要原因之一 ,并对肿瘤发生、发展具有一定影响 ,其修复主要是通过 HR和 NHEJ两条重组途径完成的。本文综述了国外近来对 DSB重组修复的 HR和 NHEJ途径 ;其与肿瘤抑制蛋白如 P5 3、ATM、BRCA1和 BRCA2之间的联系 ;DSB重组修复异常与某些肿瘤及具有肿瘤易感特征的共济失调性毛细血管扩张症和 Nijmegen断裂综合征等疾病之间关系的研究进展
DNA damage is not timely and effective repair can lead to genomic instability and increase the incidence of cancer. DSB is one of the main causes of gene mutation and chromosomal rupture, and has some influence on tumorigenesis and development. Its repair is mainly accomplished by two recombination ways of HR and NHEJ. This review summarizes recent foreign HR and NHEJ pathways for DSB recombination repair; its association with tumor suppressor proteins such as P5 3, ATM, BRCA1, and BRCA2; abnormalities of DSB recombination repair with certain tumors and features of tumor susceptibility Research progress on the relationship between ataxia telangiectasia and Nijmegen’s rupture syndrome