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目的探讨事件相关电位中（ＥＲＰ）Ｐ３００指标对ＡＩＣＡ患者认知功能的预测价值。方法检查３２例ＡＩＣＡ患者急性期ＥＲＰ，并依据病后６～８个月复合认知指数标准，分为痴呆和非痴呆组对比Ｐ３００，并与健康人比较。结果痴呆和非痴呆组Ｐ３００改变呈同一方向即波幅下降，潜伏期延长。进一步分析发现痴呆组Ｐ３００潜伏期较非痴呆组延长，波幅下降（ Ｐ＜ ０． ０５或 ０． ０１）。结论 Ｐ３００改变可优于量表，结合临床后可作为 ＡＩＣＡ患者急性期认知功能评定的预测手段。
Objective To investigate the predictive value of P300 in incident-related potentials (AFPs) in the cognitive function of patients with AICA. Methods 32 patients with acute phase of AICA were examined for ERP. According to the composite cognitive index of 6-8 months after illness, the patients were divided into two groups: P300 with dementia and non-dementia, and compared with healthy controls. Results Dementia and non-dementia group P300 changes in the same direction that the amplitude decreased, the incubation period is prolonged. Further analysis found that the latency of P300 in dementia group was longer than that in non-dementia group, and the amplitude was decreased (P <0.05 or 0.01). Conclusions The change of P300 may be better than that of scale, which can be used as a predictive measure in acute phase of cognitive function in patients with AICA.