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肿瘤细胞对多种结构、功能和杀伤靶点迥然不同的抗肿瘤药物同时产生交叉耐药性 ,称之为多药耐药性 (ｍｕｌｔｉｄｒｕｇｒｅｓｉｓｔａｎｃｅ ,ＭＤＲ)。这种多药耐药性的分子生物学基础是多药耐药基因 (ｍｄｒ1)过度表达Ｐ 糖蛋白 (Ｐ ｇｐ)。Ｐ ｇｐ是一种相对分子质量为 170
Tumor cells produce cross-resistance to multiple antineoplastic agents that are distinctly different in their structure, function and target of killing, and are called multidrug resistance (MDR). The molecular basis of this multidrug resistance is the overexpression of the P-glycoprotein (Pgp) by the multidrug resistance gene (mdr1). P gp is a relative molecular mass of 170