我院血库采用枸椽酸钠、枸椽酸、葡萄糖、腺嘌呤磷酸盐(简称 ACD、Apo_4)保存血液,能进一步延长血液的有效保存期,据报导腺嘌呤对动物肾脏有一定的毒性,但对免疫功能有无影响尚未见报导。因此,我们用免疫学的方法观察 Apo_4对实验动物免疫功能的影响。材料与方法一、动物:重18—22g 50天 ALGA 小鼠,按体重配对随机分配于实验组和对照组。实验组按500mg/kg/次(为成人每次输血200—600ml 的100—50倍),尾静脉注入 Apo_4 Our hospital blood bank using sodium citrate, citrate acid, glucose, adenine phosphate (referred to as ACD, Apo_4) to save the blood can further extend the effective preservation of blood, it was reported that adenine has some toxicity to animal kidneys, but No effect on immune function has not been reported. Therefore, we used immunological methods to observe the impact of Apo_4 on immune function in experimental animals. Materials and methods First, the animals: weighing 18-22g 50 days ALGA mice were randomly assigned to the experimental group and the control group according to body weight paired. Experimental group at 500mg / kg / time (200-600ml for each adult blood transfusion 100-50 times), tail vein injection of Apo_4