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目的研究硒对氟中毒大鼠体内氟、抗氧化酶和脂类代谢的影响作用。方法Ｗｉｓｔａｒ大鼠饮２．６３ｍｍｏｌ／Ｌ高氟水１０个月后分为氟、氟加２．０ｍｇ／ｋｇ硒、改饮正常水、改正常水加硒４组，再喂养１０个月。观察尿氟动态变化，测定骨、组织、血清氟和硒，同时测血ＧＳＨ－ｐｘ、ＳＯＤ、ＬＰＯ及血ＴＣ、ＴＧ、ＨＤＬ－Ｃ、ＬＤＬ－Ｃ等。结果氟加硒组较氟中毒组尿氟排泄增高，骨、组织氟降低，酶和脂代谢改善；改正常水加硒组，排尿氟和降体氟作用优于单纯改水组，酶和脂类指标水平更趋正常。结论一定浓度范围内的硒对氟中毒大鼠具有排高氟和调整自由基、脂类代谢紊乱作用。改正常水加硒则有促进氟中毒恢复的作用。
Objective To study the effect of selenium on fluoride, antioxidant enzymes and lipid metabolism in rats with fluorosis. Methods Wistar rats drinking 2.63mmol / L of high-fluoride water 10 months later divided into fluoride, fluoride and 2.0mg / kg of selenium, to drink normal water, normal water plus selenium group 4, and then fed for 10 months. The dynamic changes of urinary fluoride were observed. The bone, tissue and serum fluorine and selenium were measured. At the same time, GSH-px, SOD, LPO and TC, TG, HDL-C and LDL-C were measured. Results Compared with fluorosis and selenium groups, fluoride excretion increased urinary fluoride excretion, bone and tissue fluoride decreased, and enzyme and lipid metabolism improved. Compared with pure water and selenium group, Class indicators more normal level. Conclusion Selenium at a certain concentration range has the effect of increasing fluoride and regulating free radicals and dyslipidemia in rats with fluorosis. Correct water plus selenium has the role of promoting fluoride poisoning recovery.