血栓性血小板减少性紫癜(简称TTP)是一种病因及发病机理不明的血液病,其主要病理改变是血小板明显减少伴广泛的微血管内皮损害、血栓形成和弥散性血管内凝血(DIC)。病情多险恶,死亡率高。本病多为急性起病,其临床表现因受累器官较多而呈多样性,典型病例有如下五联征:①约占98％的患者发热,热型不规则。②微血管病性溶血性贫血,半数以上者有黄疸。③约90％的患者有出血表现,以皮肤及视网膜出血多见,尿血、鼻衄、便血、月经过多次之。④神经精神症状:包括头痛、眩晕、感觉异常、视力障碍、言语不清、精神错乱、谵语、晕厥、瘫痪、抽搐、昏迷等,其特点是变化不定,多 Thrombotic thrombocytopenic purpura (referred to as TTP) is a cause and pathogenesis of unknown blood disease, the main pathological changes are significantly reduced platelet with extensive microvascular endothelial damage, thrombosis and disseminated intravascular coagulation (DIC). More dangerous conditions, high mortality. The disease is mostly acute onset, the clinical manifestations due to the involvement of more organs and diversity, typical cases have the following five levy: ① about 98% of patients with fever, fever type irregular. ② microangiopathic hemolytic anemia, more than half of those who have jaundice. ③ About 90% of patients have bleeding performance, more common skin and retinal hemorrhage, hematuria, epistaxis, blood in the stool, menstrual many times. ④ neuropsychiatric symptoms: including headache, dizziness, sensory abnormalities, visual impairment, slurred speech, confusion, sufferers, syncope, paralysis, convulsions, coma, etc., which is characterized by volatility, and more