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本文在冠心病、心肌梗塞后患者中用硝酸异山梨酯(ISDN,Isoket)中等剂量静脉滴注,发现用药前后心率、主动脉舒张压、左室收缩压力最大上升速率、心率血压乘积均无显著变化,而左室舒张末期压力(LVEDP)显著下降,左室心肌灌注压力显著升高,提示对心肌缺血的改善有利。用药后LVEDP显著降低而左室收缩压力最大上升速率保持不变,提示用药后左心室能在较低负荷状态下完成同样的收缩作功。
In this paper, coronary heart disease, myocardial infarction patients with isosorbide dinitrate (ISDN, Isoket) medium dose intravenous infusion, found that before and after treatment, heart rate, aortic diastolic blood pressure, left ventricular systolic blood pressure, maximum rate of increase, Changes, and left ventricular end diastolic pressure (LVEDP) decreased significantly, left ventricular myocardial perfusion pressure was significantly elevated, suggesting that myocardial ischemia improved. After treatment LVEDP significantly reduced the maximum rate of left ventricular systolic pressure rise rate remained unchanged, suggesting that the left ventricle after treatment can be done under the condition of a lower load the same work of contraction.