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目的:探讨液基薄层细胞(TCT)结果为ASCUS的临床处理对策。方法:回顾性分析TCT结果为ASCUS并同时检测了高危型人乳头瘤病毒(HPV)DNA和阴道镜下活检、最后以活检病理结果为诊断标准的患者144例。结果:合并HPV感染35例,其余109例为HPV阴性。活检病理结果为宫颈炎123例,宫颈上皮内瘤变(CIN)21例,CIN阳性率14.58%(21/144)。HPV阳性35例中CINⅠ6例,CINⅡ5例,CINⅢ2例,阳性率37.14%;HPV阴性109例中CINⅠ7例,CINⅡ1例,CINⅢ0例,阳性率7.34%,差异有统计学意义(P<0.05)。结论:ASCUS合并高危型HPV感染患者更易潜在CIN、甚至高级别CIN,高危型HPV-DNA检测可以将ASCUS合理分流,并指导合理使用阴道镜及镜下定位活检。
Objective: To investigate the clinical treatment of ASCUS based on the results of liquid-based thin-layer cells (TCT). Methods: A retrospective analysis of TCT results ASCUS and simultaneous detection of high-risk human papillomavirus (HPV) DNA and colposcopy biopsy, and finally the biopsy results of the diagnosis of 144 patients. Results: There were 35 cases with HPV infection, the other 109 cases were HPV negative. Biopsy results of 123 cases of cervicitis, cervical intraepithelial neoplasia (CIN) in 21 cases, CIN positive rate of 14.58% (21/144). There were 6 cases of CINⅠ, 5 cases of CINⅡ and 2 cases of CINⅢ, the positive rate of HPV was 37.14%. There were 7 cases of HPV negative in CINⅠ, 1 case of CINⅡ and 0 cases of CINⅢ, with a positive rate of 7.34% (P <0.05). CONCLUSIONS: Patients with ASCUS complicated with high-risk HPV infection are more likely to have CIN or even higher-grade CIN. The high-risk HPV-DNA test can be used to bypass ASCUS and guide the rational use of colposcopy and endoscopic biopsy.