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早在本世纪初就已发现某些染料如吖啶橙、伊红等在可见光照射下能显示荧光和杀伤与之结合的细胞。这种物质称作光敏化剂,其在光照下产生的反应称为光敏效应。此后发现某些卟啉类化合物也能产生光敏效应。1961年研制成新型的光敏化剂——血卟啉衍生物(HPD),以激光作为光源,用导光纤维内窥镜将光线引入体内以诊断和治疗肿瘤后,这方法才受到日益广泛的重视。目前,国内外许多单位正在就HPD 制剂、激光装置,光敏效应的机制及应用等方面展开研究。本文拟就近年来国内外有关血卟啉衍生物光敏效应机制及其在肿瘤诊治中的应用研究概况作一简略介绍。
As early as the beginning of this century, certain dyes such as acridine orange, eosin, etc. have been shown to display fluorescence and kill cells bound thereto under visible light irradiation. This substance is called a photosensitizer, and its reaction under light is called photosensitizing effect. Since then, some porphyrins have also been found to produce photosensitizing effects. In 1961, he developed a novel photosensitizer, the hematoporphyrin derivative (HPD). This method was increasingly popular after the laser was used as a light source to introduce light into the body with a fiber-optic endoscope to diagnose and treat tumors. Pay attention. At present, many units at home and abroad are conducting research on HPD preparations, laser devices, mechanisms and applications of photosensitizing effects. This article intends to briefly introduce the research on the mechanism of photosensitizing effect of hematoporphyrin derivatives and their application in the diagnosis and treatment of cancer in recent years.