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由于胰岛素分泌绝对不足,1型糖尿病(T1DM)患者需终生胰岛素替代治疗以维持生命。胰岛素的治疗方案应尽可能模拟生理性胰岛素分泌的模式,包括基础胰岛素和餐时胰岛素两部分的补充。DCCT及后续的EDIC研究显示,对1型糖尿病患者进行强化治疗有助于将血糖降至接近正常水平,并能显著降低最严重眼病、肾功能受损、心脏病及卒中的发生风险[1,2]。DCCT试验的结果显示,与常规治疗相比,旨在使血糖降至接近
Because of the absolute lack of insulin secretion, patients with type 1 diabetes (T1DM) require life-long insulin replacement therapy. Insulin treatment options should be as much as possible to simulate the physiological pattern of insulin secretion, including basal insulin and mealtime insulin two parts of the supplement. DCCT and subsequent EDIC studies have shown that intensive treatment of patients with type 1 diabetes helps to bring blood glucose to near-normal levels and significantly reduces the risk of the most severe eye diseases, impaired renal function, heart disease and stroke [1, 2]. The results of the DCCT trial show that blood glucose is intended to be brought closer than conventional treatment