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目的探讨宫颈癌患者放化疗前后血清鳞状上皮细胞癌抗原(SCCAg)与生物学行为的相关性及临床意义。方法采用全自动酶免疫微粒法检测220例宫颈癌患者治疗前后SCCAg值,分析SCCAg检测值与宫颈癌临床、病理特征之间的关系。结果宫颈癌患者治疗前血清SCCAg水平与肿瘤组织学类型、大小、生长类型、临床分期相关(P<0.05),与肿瘤分化程度无关(P>0.05),治疗后SCCAg水平明显低于治疗前(P<0.01)。结论治疗前后血清SC-CAg值对估计宫颈癌的生物学行为及评价治疗效果有重要的参考价值。
Objective To investigate the correlation and clinical significance of serum squamous cell carcinoma antigen (SCCAg) with biological behavior before and after radiotherapy and chemotherapy in patients with cervical cancer. Methods The levels of SCCAg in 220 patients with cervical cancer before and after treatment were detected by automatic enzyme immunoassay. The relationship between SCCAg and the clinical and pathological features of cervical cancer was analyzed. Results The serum level of SCCAg in cervical cancer patients before treatment was correlated with tumor histological type, size, growth type and clinical stage (P <0.05), but not with tumor differentiation (P> 0.05). The SCCAg level in patients with cervical cancer was significantly lower than that before treatment P <0.01). Conclusions The serum SC-CAg values before and after treatment have important reference values for estimating the biological behavior of cervical cancer and evaluating the therapeutic effect.