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目的观察低T3综合征的心力衰竭(LT3S-CHF)患者血浆内皮素(ET)和甲状腺激素(TH)水平变化及其与心力衰竭严重程度的关系。方法选择46例确诊的LT3S-CHF患者作为病变组,46例健康人为对照组。入选者均于清晨空腹采血,用放射免疫法测定ET和TH含量变化,并进行比较。结果LT3S-CHF患者ET水平明显高于正常对照组(P<0.01),且随着心功能级数的升高浓度也逐步升高(P<0.01),同时T3、FT3浓度下降明显(P<0.05),而T4、FT4、TSH无明显变化。结论心力衰竭患者血浆内皮素和T3、FT3浓度变化与心力衰竭的程度密切相关。
Objective To observe the changes of plasma endothelin (ET) and thyroid hormone (TH) in patients with low T3 syndrome and its relationship with the severity of heart failure. Methods Forty-six patients with LT3S-CHF were selected as pathological group and 46 healthy people as control group. The participants were fasting fasting blood samples were used radioimmunoassay determination of ET and TH content changes, and compared. Results The level of ET in LT3S-CHF patients was significantly higher than that in the normal controls (P <0.01), and the level of cardiac function was also increased (P <0.01), while the concentrations of T3 and FT3 decreased significantly (P < 0.05), while T4, FT4, TSH no significant change. Conclusion The changes of plasma endothelin, T3, FT3 concentrations in patients with heart failure are closely related to the degree of heart failure.