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目的:比较吸烟成瘾男性与健康对照组静态及动态自发性脑活动的差异，探索吸烟成瘾机制。方法:基于静态低频振幅(static amplitude of low frequency fluctuation，sALFF)和动态低频振幅(dynamic amplitude of low frequency fluctuation，dALFF)方法，采用独立样本n t检验比较男性吸烟成瘾组(n n＝63)和健康对照组(n n＝30)静态及动态脑自发活动差异。采用Pearson相关分析探讨吸烟成瘾组dALFF值的变化与烟草依赖评估得分(Fagerstr?m test for nicotine dependence，FTND)、吸烟指数(包年数)的相关性。n 结果:与健康对照组相比，吸烟成瘾组在左侧额上/中/下回、左侧眶额回(n t＝5.17，升高区≥108个)区域sALFF活动增加；在右侧颞上/中回、左侧额眶区、左侧眶部额上/中/下回、右侧眶额回/额中/下回、右侧壳核(n t＝4.90，4.37，4.91，4.62，4.59，变异区≥96个)dALFF变异性增加。吸烟成瘾组右侧颞上/中回(n r＝0.252，n P＝0.047)、左侧眶部额上回(n r＝0.281，n P＝0.026)、右侧壳核(n r＝0.313，n P＝0.012)dALFF的时间变异性与吸烟指数呈正相关。n 结论:吸烟成瘾者静息状态下前额叶皮层(包括眶额叶)、壳核、颞上/中回的脑固有自发神经活动和动态自发神经活动强度增加，且这些脑区功能活动改变与吸烟成瘾者吸烟指数有关。“,”Objective:To explore the differences of static and dynamic spontaneous brain activity between male smoking addicts and healthy controls, and analyze the mechanism of smoking addiction.Methods:Based on static amplitude of low-frequency fluctuation (sALFF) and dynamic amplitude of low frequency fluctuation (dALFF), the differences of static and dynamic spontaneous brain activity were compared between male smoking addicts (n n=63) and healthy controls (n n=30) by independent sample n t-test. Pearson correlation analysis was used to investigate the relationships between the altered dALFF values and score of Fagerstr?m test for nicotine dependence(FTND) and pack-years of smoking addicted males.n Results:Compared with healthy controls, the values of sALFF in the left superior/middle/inferior orbitofrontal gyrus (n t=5.17, clusters≥108) were increased and the variation of dALFF in the right superior temporal/middle gyrus, left orbitofrontal region, left orbital superior/middle/inferior frontal gyrus, right orbitofrontal gyrus/middle/inferior frontal gyrus and right putamen (n t=4.90, 4.37, 4.91, 4.62, 4.59, clusters≥96) were also increased in the smoking addicted group. It was noteworthy that the dALFF values of the right superior temporal/middle gyrus(n r=0.252, n P=0.047), left orbital region superior frontal gyrus(n r=0.281, n P=0.026) and right putamen(n r=0.313, n P=0.012) were positively correlated with pack-years of male smoking addicts.n Conclusion:Male smoking addicts may have abnormal static and dynamics spontaneous neural activity in prefrontal cortex (including orbital frontal lobe), putamen and superior temporal/middle gyrus, which are correlated with pack-years.