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目的探讨妊娠期梅毒母婴阻断治疗对妊娠结局及新生儿预后的影响。方法选取60例妊娠合并梅毒患者作为研究对象,其中30例在妊娠期实施母婴阻断治疗(观察组),30例在妊娠期未实施母婴阻断治疗(对照组),比较两组患者的妊娠结局及新生儿预后。结果观察组的早产、死产、流产率均显著低于对照组(P<0.05),正常产率显著高于对照组(P<0.05)。观察组的低体重儿、新生儿窒息、新生儿死亡、先天梅毒发生率均显著低于对照组(P<0.05)。两组新生儿娩出后的抗梅毒螺旋体抗体检测结果均呈阳性,快速血浆反应素检测阳性40例(66.67%)。RPR阳性新生儿在12个月内有30例转阴,占75.00%,随访至1.5岁,复查显示抗-TP转阴46例,占76.67%。结论对于妊娠合并梅毒患者早期实施规范的母婴阻断治疗,能够有效降低死产、流产等不良妊娠结局发生率,同时减少新生儿先天性梅毒的发生,改善新生儿预后。
Objective To investigate the effect of blocking treatment of syphilis in pregnant women on pregnancy outcome and prognosis of neonates. Methods Sixty pregnant women with syphilis were enrolled in this study. Among them, 30 were treated with maternal and childbirth block during pregnancy (observation group) and 30 were not treated with maternal and infant block during pregnancy (control group). The patients in two groups were compared Pregnancy outcome and neonatal prognosis. Results The rate of preterm birth, stillbirth and abortion in the observation group were significantly lower than those in the control group (P <0.05). The normal birth rate was significantly higher than that in the control group (P <0.05). The incidence of neonatal asphyxia, neonatal death and congenital syphilis in observation group was significantly lower than that in control group (P <0.05). Tests of anti-Treponema pallidum antibodies were positive in both groups after delivery, and 40 (66.67%) were positive for rapid plasma testin. RPR positive newborns within 30 months, 30 cases of negative, accounting for 75.00%, followed up to 1.5 years old, the review showed anti-TP negative in 46 cases, accounting for 76.67%. Conclusion The early implementation of standardized maternal and child block treatment in patients with syphilis during pregnancy can effectively reduce the incidence of adverse pregnancy outcomes such as stillbirth and miscarriage, reduce the incidence of congenital syphilis in neonates and improve the prognosis of neonates.