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卡氏肺囊虫肺炎(PCP)是获得性免疫缺陷综合征(AIDS)患者最常见的条件致病性感染。用 TMP-SMZ 治疗效果明显,但复发率较高。动物实验和 AIDS 患者研究表明,TMP-SMZ 或戊脘脒均不能杀灭卡氏肺囊虫。曾有报道,TMP-SMZ 可用以预防白血病患儿发生肺囊虫病。但是该药可使AIDS 患者产生超敏反应和严重副作用。作者试用乙胺嘧啶-N 效磺胺联合剂(比例1∶20)预防 AIDS 患者的 PCP。
Pneumocystis carinii pneumonia (PCP) is the most common opportunistic infection in patients with Acquired Immune Deficiency Syndrome (AIDS). With TMP-SMZ treatment effect is obvious, but the recurrence rate is higher. Animal experiments and AIDS patients showed that neither TMP-SMZ nor pentamidine killed Pneumocystis carinii. It has been reported that TMP-SMZ can be used to prevent the occurrence of pulmonary cysticercosis in children with leukemia. However, the drug can cause hypersensitivity reactions and serious side effects in AIDS patients. The authors trial pyrimethamine-N-sulfonamide combination agent (ratio 1:20) to prevent PCP in AIDS patients.