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目的探讨川崎病患儿成纤维细胞生长因子(FGF)-23基因多态性、血清表达水平及对心脏病易感性的影响。方法选取2013年1月~2015年1月我院收治的90例川崎病患儿,检测90例患儿的FGF-23基因内含子多态性及心脏病的发生情况,根据患儿FGF-23的不同基因型将其分成FGF-23基因多态性组和FGF-23基因野生型组,比较两组患儿的血清FGF-23水平、血清相关指标及心脏病变易感性。结果本研究90例川崎病患儿中,FGF-23基因野生性组患儿64例,所占比例为71%,FGF-23基因多态性组患儿26例,所占比例为29%;FGF-23基因多态性组男性比例及血清FGF-23水平[92%,(41±15)ng/L]显著高于对照组[62%,(11±13)ng/L,P<0.05];FGF-23基因多态性组患儿冠状动脉扩张、冠状动脉瘤以及心脏受累发生率均显著高于FGF-23基因野生性组(P<0.05);Logistic回归多因素分析发现血清FGF-23水平与川崎病患儿心血管病变的发生率显著相关(P<0.01)。结论 FGF-23基因多态性的川崎病患者血清FGF-23水平显著增高,且冠状动脉异常几率增大。
Objective To investigate the genetic polymorphisms of fibroblast growth factor (FGF) -23 in children with Kawasaki disease and its influence on the susceptibility to heart disease. Methods Ninety children with Kawasaki disease who were admitted to our hospital from January 2013 to January 2015 were enrolled in this study. The polymorphisms of FGF-23 gene and the incidence of heart disease were detected in 90 children. According to FGF- 23 were divided into two groups: FGF-23 gene polymorphism group and FGF-23 gene wild type group. Serum FGF-23 levels, serum-related indicators and susceptibility to heart disease were compared between the two groups. Results In the 90 children with Kawasaki disease, 64 cases of FGF-23 gene wild type group accounted for 71%, 26 cases of FGF-23 gene polymorphism group, accounting for 29%. The male ratio and the serum level of FGF-23 [92%, (41 ± 15) ng / L] in the FGF-23 gene polymorphism group were significantly higher than those in the control group (62%, 11 ± 13 ng / L, (P <0.05). Logistic regression analysis showed that the serum levels of FGF-23 in the FGF-23 gene polymorphism group were significantly higher than those in the FGF-23 wild type group (P <0.05) 23 level was significantly associated with the incidence of cardiovascular disease in children with Kawasaki disease (P <0.01). Conclusion The serum level of FGF-23 in patients with Kawasaki disease with FGF-23 gene polymorphisms is significantly increased, and the abnormal probability of coronary artery is increased.