用D-氨基半乳糖(D-GalN)制备大鼠急性肝损伤模型,检测血清谷丙转氨酶(ALT)、谷草转氨酶(AST)和肝匀浆超氧化物歧化酶(SOD)、丙二醛(MDA)含量,观察肝组织病理变化,以探讨中药蛇葡萄根对急性肝损害的保护作用。结果显示:蛇葡萄很能显著降低血清ALT、AST含量,提高SOD含量,降低MDA含量,高剂量组还能减轻肝细胞受损程度。提示蛇葡萄根具有保肝降酶及抗自由基损伤作用。 Acute hepatic injury model in rats was prepared with D-galactosamine (D-GalN) and serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and liver homogenate superoxide dismutase (SOD) and malondialdehyde were detected. MDA) content, observe the pathological changes of liver tissue, in order to explore the protective effect of Chinese herb snake grape root on acute liver damage. The results showed that: Snake grape can significantly reduce serum ALT, AST content, increase SOD content, reduce MDA content, high dose group can also reduce the degree of liver cell damage. It is suggested that snake grape root has the functions of hepatoprotection and anti-free radical damage.