不寻常的体征一、胫骨前粘液性水肿:可以表现为高起的红斑状结节,有点象结节性红斑;亦可呈弥漫性块状隆起,表面桔皮样,或者表现为双侧弥漫性对称性木质状浸润,很象淋巴性水肿。本征产生的原因不明,但常与甲亢性眼病同时存在,且与甲亢性眼病一样常在甲亢症状出现多年后才发生。虽然其出现与血清中长效甲状腺刺激因子(Long-acting thyroid stimulator,简称LATS)的增加密切相关,但尚未证实LATS就是其病因。二、指甲的改变。主要为营养性改变,即指甲出现纵横行的纹理,失去正常凸度,常呈微凹形,远端略翘起,象个杓子。最显著的是指甲与其下的软组织呈不规则的分离,以致脏物进入后很难清除,从而形成一条不规则的黑色带。但这些变化常在甲亢症的其他症状明显时才表现得较清楚。 Unusual signs First, the tibialis myxedema: can be manifested as elevated erythema nodules, a bit like erythema nodosum; also showed a diffuse mass bulge, the surface of orange peel-like, or showed bilateral diffuse Sexual symmetry woody infiltrate, much like lymphoid edema. The cause of the etiology is unknown, but often with hyperthyroidism eye disease exist at the same time, and hyperthyroidism and eye disease often occur in many years after the symptoms appear. Although its appearance is closely related to the increase of serum Long-acting thyroid stimulator (LATS), LATS has not been proved to be the etiology. Second, changes in nails. Mainly for nutritional change, that is, the vertical and horizontal lines of nails texture, loss of normal convexity, often micro-concave shape, slightly tilted distal, like a ladle. Most notably, the nails are irregularly separated from the underlying soft tissue, making it difficult to remove the dirt after it enters, creating an irregular black band. However, these changes often appear when other symptoms of hyperthyroidism were clear.