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r-氨基丁酸(G A B A)在中枢神经系统内是抑制性神经递质。据报告,慢性舞蹈病(Huntington氏舞蹈病)为代表的一类神经精神性疾病患者的中枢神经系统内G A B A代谢异常。尸检发现慢性舞蹈病患者之基底核内GABA浓度减少,脑脊液内G A B A浓度亦降低。经测定的资料证实,脑内GABA浓度与脊液中的浓度成正比,故可根据脊液中的GABA浓度推测脑内GABA的代谢。众所周知,异烟肼是维生素B_6的阻碍剂。1973年Perry指出,虽然维生素B_6是GABA生成酶——谷氨酸脱羧酶与GABA分解酶——GABA转氨酶的辅酶,但异烟肼对维生素B_6的作用,在脑内主要是阻碍氨基转移反应,使得GABA分解受阻而致GABA增高。1979年该氏应用异烟肼治疗慢性舞蹈病患者,用药4～25个月而使患者症状改善。1981年Manyam等对慢性舞蹈病患者服异烟肼6周,结果使脊液中的
r-Aminobutyric acid (GABA) is an inhibitory neurotransmitter in the central nervous system. G A B A metabolism in the central nervous system has been reported in a group of patients with neuropsychiatric disorders, such as chronic chorea (Huntington’s chorea). Autopsy revealed a decrease in GABA concentration in basal ganglia and a decrease in GABA concentration in cerebrospinal fluid in patients with chronic chorea. The data confirmed that brain GABA concentration and concentration in the spinal fluid is proportional to, so the GABA concentration in spinal fluid can be estimated GABA brain metabolism. Is well known that isoniazid is a vitamin B_6 inhibitor. In 1973, Perry pointed out that although vitamin B_6 is a coenzyme of GABA-producing enzyme, glutamic acid decarboxylase and GABA-GABA transaminase, the effect of isoniazid on vitamin B-6 mainly hinders the transamination in the brain, GABA decomposition caused obstruction caused by increased GABA. In 1979, the application of isoniazid in patients with chronic chorea, medication for 4 to 25 months and make the patient’s symptoms improved. 1981 Manyam chronically chorea patients taking isoniazid 6 weeks, the result of spinal fluid