目的　研究乳腺分泌性癌的发病率、年龄和病理特点。方法　应用HE染色、淀粉酶消化后PAS及Alcianblue(AB)染色、透射电镜 (TEM)方法观察。结果　乳腺分泌性癌仅占同期全部活检乳腺癌的 0 .6 %。 4例平均年龄5 4 5岁。病理形态学的主要特点为癌细胞异型性较小 ,癌细胞能产生大量分泌物 ,对PAS及AB染色出现阳性反应。术后 12年随访 ,4例均无复发和转移。结论　乳腺分泌性癌为一种极少见的肿瘤 ,可发生于中老年女性 ,预后良好。根据其组织学特点 ,可以作出明确的病理诊断 Objective To study the incidence, age and pathological features of breast cancer. Methods HE staining, PAS and Alcianblue (AB) staining, and transmission electron microscopy (TEM) were performed after amylase digestion. Results Breast secretory cancer accounted for only 0.6% of all biopsy breast cancers in the same period. The average age of 4 patients was 545 years old. The main feature of pathological morphology is that the cancer cells are less heterozygous, cancer cells can produce a large amount of secretions, and positive reactions to PAS and AB staining. After 12 years of follow-up, none of the 4 patients had recurrence or metastasis. Conclusion Breast secretory cancer is a rare tumor that can occur in middle-aged and elderly women with a good prognosis. According to histological features, it is possible to make a clear pathological diagnosis