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狼疮性肾炎 ( Lupus nephritis,L N)的临床表现和病理改变与预后相关 ,特别是病理变化对指导临床治疗有重要意义。尽管临床表现的程度与病理损害程度有一定的关系 ,但并不完全一致 ,由于 L N发生肾功衰竭是系统性红斑狼疮 ( Systemic lupuserythematosus,SL E)的主要死亡原因之一 ,因而控制 LN的活动非常重要。积极行肾病理检查对指导临床治疗至关重要 ,预防感染发生和合理用药对降低 SLE的病死率、提高远期生存率意义重大。环磷酰胺冲击治疗和新型免疫抑制剂的临床应用为 SL E的治疗和防止肾纤维化较好的治疗途径。
The clinical manifestations and pathological changes of Lupus nephritis (L N) are related to the prognosis, especially the pathological changes are of great significance to guide the clinical treatment. Although the degree of clinical manifestations and the degree of pathological damage have a certain relationship, but not exactly the same, as LN renal failure is the systemic lupus erythematosus (Systemic lupus erythematosus, SL E) one of the major causes of death, and thus control the activity of LN Very important. Positive renal pathological examination of the guidance of clinical treatment is essential to prevent the occurrence of infection and rational use of drugs to reduce the mortality of SLE and improve long-term survival rate of great significance. Cyclophosphamide shock therapy and the clinical application of novel immunosuppressive agents for the treatment of SL E and prevention of renal fibrosis better treatment.