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[Objectives] To prepare Ibuprofen-β-CD for thermosensitive in situ gel administration to achieve a slow drug release. [Methods]By saturation solution process,the best inclusion technology was screened out with orthogonal design. [Results]The prescription of in situ gel contained ibuprofen-β-CD complex,poloxamer P407,P188,and HPMCK4M( w/v 10%,18%,3%,and 0. 5%). The gelation temperature of ibuprofen gel was 34. 6 ± 0. 3℃. The viscosity of ibuprofen gel increased significantly above 35℃ and showed semi-solid attribute. [Conclusions] The release of ibuprofen from in situ gel was slow and stable in 96 h,demonstrated a proximate zero order release between 24 h and 96 h.
[Objectives] To prepare Ibuprofen-β-CD for thermosensitive in situ gel administration to achieve a slow drug release. [Methods] By saturation solution process, the best inclusion technology was screened out with orthogonal design. [Results] The prescription of in situ gel contained ibuprofen-β-CD complex, poloxamer P407, P188, and HPMCK4M (w / v 10%, 18%, 3%, and 0.5%). The gelation temperature of ibuprofen gel was 34.6 ± 0.3 ° C. The viscosity of ibuprofen gel increased significantly above 35 ° C and showed semi-solid attribute. [Conclusions] The release of ibuprofen from in situ gel was slow and stable in 96 h, demonstrated a proximate zero order release between 24 h and 96 h .