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甲硝唑是当今公认的首选抗厌氧菌药,临床主 要用于治疗和预防厌氧菌引起的腹腔、消化道、女 性生殖系、下消化道、皮肤及软组织、骨和关节等感 染。笔者就医院制剂室制备甲硝唑葡萄糖注射液时 易出现的质量问题归纳如下,供参考。 1 活性炭对甲硝唑的吸附作用 配制甲硝唑葡萄糖注射液的过程中,发现活性 炭对甲硝唑有很强的吸附作用,按常规进行配制, 加入活性炭0.05％,甲硝唑含量低于95版药典规 定的7％,且随着活性炭量的增加其含量逐渐下降。
Metronidazole is now recognized as the preferred anti-anaerobic bacterium, which is mainly used for the treatment and prevention of anaerobic infections in the abdominal cavity, digestive tract, female reproductive system, lower digestive tract, skin and soft tissue, bone and joint. The author of the preparation of the hospital preparation room metronidazole glucose injection prone quality problems summarized as follows for reference. 1 Activated carbon adsorption of metronidazole Formulation metronidazole glucose injection process and found that activated carbon has a strong adsorption of metronidazole, according to conventional preparation, adding 0.05% activated carbon, metronidazole content of less than 95 Pharmacopoeia version of the provisions of 7%, and with the increase in the amount of activated carbon its content decreased.