TPN导致新生儿胆汁郁积的确切原因,至今仍不清楚。本文作者对接受TPN的新生儿病例进行了回顾性分析,旨在从临床及营养成分等方面寻找原因。选择经TPN治疗至少1周的新生儿172例(男婴92例,女婴80例),行TPN超过7周者32例,分组予以观察。74例最少作过一次手术。接受TPN的时间最少为1周,最多为12周。病孩均行周围静脉TPN,补充12.5％葡萄糖和2.5％结晶氨基酸;病程超过3～4周者改用中心静脉TPN,补充25％葡萄糖和3.5％结晶氨基酸。均用脂肪乳剂(Liposyn和Intralipid)以提供40％/d热卡量。测定患儿 The exact reason why TPN causes cholestasis in neonates remains unclear. The authors performed a retrospective analysis of neonatal cases receiving TPN in order to find out the reasons from clinical and nutritional aspects. A total of 172 newborns (92 infants and 80 infants) undergoing TPN therapy for at least 1 week were enrolled. Thirty-two neonates with TPN more than 7 weeks were selected and divided into groups for observation. 74 patients had at least one operation. The time to receive TPN is at least 1 week, up to 12 weeks. The patients underwent peripheral venous TPN supplemented with 12.5% ​​glucose and 2.5% crystalline amino acids. Patients with a duration of more than 3 to 4 weeks switched to central venous TPN supplemented with 25% glucose and 3.5% crystalline amino acids. Fat emulsions (Liposyn and Intralipid) are used to provide 40% of the calories per day. Determination of children