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目的探讨马来酸曲美布汀联合双歧四联活菌治疗便秘型肠易激综合征的临床疗效。方法将52例便秘型肠易激综合征患者随机分为2组,治疗组给予马来酸曲美布汀胶囊联合双歧四联活菌,对照组单独给予双歧四联活菌,比较两组疗效差异。结果对照组26例患者,总有效率为84.62%,治疗组26例患者,总有效率为92.31%,两组疗效经χ2检验,χ2=15.04,P<0.01,治疗组与对照组之间的疗效有显著性差异。结论马来酸曲美布汀联合双歧四联活菌治疗便秘型肠易激综合征效果明显,且强于单独使用双歧四联活菌。
Objective To investigate the clinical efficacy of trimebutine maleate combined with bifidobacterium live in the treatment of constipation-type irritable bowel syndrome. Methods Fifty-two patients with constipation-type irritable bowel syndrome were randomly divided into two groups. The treatment group was given trimebutine maleate combined with bifidobacterium viable, the control group was given bifidobacterium viable alone, Group differences in efficacy. Results The control group of 26 patients, the total effective rate was 84.62%, the treatment group of 26 patients, the total effective rate was 92.31%, the two groups by χ2 test, χ2 = 15.04, P <0.01, between the treatment group and the control group There are significant differences in efficacy. Conclusions Trimebutine maleate and bifidobacterium live in the treatment of constipation-induced irritable bowel syndrome is more effective than bifidobacterium alone.