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众所周知,DNA是由两个长链DNA分子彼此依靠两对专一性的碱基,如腺嘌呤(A)-胸腺嘧啶(T),胞嘧啶(C)-鸟嘌呤(G)间的氢键作用而形成的一个双螺旋结构分子。因此近来在核酸类似物的研究中,人们对含有一对核酸碱基A与T作为悬挂基的核酸类似物的研究给予很大重视。其理由是在大分子链上含有一对A与T作为悬挂基的模型化合物,在其结构与性能上比只有一个A或T的模型更为接近天然的DNA。但由于合成上的困难,对这
It is well-known that DNA consists of two long-chain DNA molecules that rely on two specific pairs of bases, such as hydrogen bonds between adenine (A) thymine (T) and cytosine (C) guanine A double helix molecule formed. Therefore, in recent studies on nucleic acid analogues, much attention has been given to the study of nucleic acid analogs containing a pair of nucleic acid bases A and T as a pendant group. The reason for this is that the macromolecular chain contains a pair of A and T as a pendant-based model compound, which is more similar in structure and properties to a natural DNA than a single A or T model. But due to synthetic difficulties, this is