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为探讨Ｒｂ及ｃｄｋ４在非小细胞肺癌中的表达，及其与肺癌发生、组织学类型及分化程度的关系。用ＬＳＡＢ免疫组织化学染色的方法研究１０４例手术切除非小细胞肺癌组织，其中２７９％的病例完全不表达ｐＲｂ；８４５％的肿瘤表达ｃｄｋ４，且表达随细胞分化程度的降低而升高，强度增强。结果提示ｐＲｂ及ｃｄｋ４的表达异常在肺癌的发生和组织类型上起重要作用，其中ｃｄｋ４对肺癌的组织分化程度起重要作用。
To investigate the expression of Rb and cdk4 in non-small cell lung cancer, and its relationship with the occurrence, histological type and differentiation of lung cancer. LSAB immunohistochemical staining method was used to study 104 cases of surgically resected non-small cell lung cancer tissues, of which 27,9% did not express pRb at all; 84.5% of the tumors expressed cdk4, and the expression increased as the degree of cell differentiation decreased. High, increased strength. The results suggest that the abnormal expression of pRb and cdk4 plays an important role in the occurrence and organization of lung cancer, among which cdk4 plays an important role in the degree of tissue differentiation of lung cancer.