论文部分内容阅读
生长抑素(SS)于1973年首次从羊的下丘脑提取,为14个氨基酸构成的环状多肽,其第3位和第14位氨基酸之间以二硫键相连,分子量为1637。除中枢神经系统的神经节细胞外,SS还存在于周围神经、胃窦、十二指肠、胰腺等组织;在甲状腺、下颌下腺、胎盘等也有少量SS。近年研究证实,SS除具有抑制GH分泌的作用外,还抑制垂体分泌TSH、PRL等。对胃肠道功能有广泛的影响;对胰腺内、外分泌功能均有抑制作用,尚可减少内脏血流中,提高内脏血管阻力。动物及临床研究显示SS有抑制恶性肿瘤生长作用,如胰腺癌、乳癌、
Somatostatin (SS) was first extracted from the hypothalamus of sheep in 1973. It is a cyclic peptide consisting of 14 amino acids. The third and 14th amino acids are disulfide linked with a molecular weight of 1637. In addition to the central nervous system ganglion cells, SS also exists in the peripheral nerves, gastric antrum, duodenum, pancreas and other tissues; in the thyroid gland, submandibular gland, placenta also have a small amount of SS. In recent years, studies have confirmed that, in addition to the role of SS inhibition of GH secretion, but also inhibit pituitary TSH, PRL and so on. Gastrointestinal function has a wide range of effects on the pancreatic and exocrine functions are inhibited, still can reduce visceral blood flow, increase visceral vascular resistance. Animal and clinical studies have shown that SS can inhibit the growth of malignant tumors, such as pancreatic cancer, breast cancer,