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目的分析静脉注射氨曲南发生ADR的影响因素,为临床安全用药提供参考。方法抽取我院2006年至2010年静脉注射氨曲南患者的完整住院病历,对发生ADR的住院患者和未发生ADR的住院患者进行病例对照研究,应用非条件Logistic回归模型完成单因素及多因素分析。结果单因素分析具有显著意义(P<0.05)影响因素有4个:即年龄、原患疾病的严重程度、用药天数、过敏史,将其引入Logistic回归方程,经假设检验回归系数均有统计学意义(P<0.05),且用药天数的回归系数为负值,而年龄、原患疾病严重程度、过敏史变量的Exp(β)的值均大于1。结论年龄、过敏史、用药天数、原患疾病的严重程度对不良反应的发生有显著意义,且高龄、有过敏史、严重的原患疾病可导致发生不良反应的相对危险度增加。
Objective To analyze the influencing factors of ADR caused by intravenous aztreonam and provide references for clinical safety. Methods The complete hospitalization records of patients receiving aztreonam intravenously in our hospital from 2006 to 2010 were drawn. Case-control study was carried out on hospitalized patients with ADR and inpatients without ADR. Unconditional Logistic regression model was used to complete single-factor and multi-factor analysis. The results of univariate analysis was significant (P <0.05), there are four influencing factors: age, the severity of the original disease, the number of days of treatment, allergy history, the introduction of Logistic regression equation, the hypothesis test regression coefficients were statistically (P <0.05), and the regression coefficient of days of medication was negative, while the values of Exp (β) of age, original disease severity and allergic history variables were both greater than 1. Conclusions Age, history of allergy, number of days of treatment and the severity of the original disease have significant effects on the occurrence of adverse reactions. In addition, the elderly have a history of allergies. The serious risk of the original disease can cause an increase in the relative risk of adverse reactions.