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阻断狗冠脉左前降支血流后,缺血区局部静脉血流变特性出现明显、稳定的异常变化。缺血40min时低切变率(r=1.15s~(-1))全血粘度已明显升高(从对照值的39±7.9mPa.s增加到58±8.4mPa.s),这一变化出现在血浆纤维蛋白原浓度与HCT明显变化之前,提示急性心肌缺血早期血液粘度的异常增高除血浆纤维蛋白原与HCT的影响外,可能还有另外一些尚未阐明的快速调节机制参与。缺血区局部血液高切变率下(r=230s~(-1))全血粘度升高程度明显大于体循环静脉血,这可能与缺血区酸性代谢产物蓄积、H~+浓度增高以及氧分压降低有关。
After blocking the left anterior descending branch blood flow of dog coronary artery, the local venous blood rheological characteristics of ischemic area showed obvious and stable abnormal changes. The whole blood viscosity of low shear rate (r = 1.15s -1) at 40min after ischemia increased significantly (from 39 ± 7.9mPa.s to 58 ± 8.4mPa.s at the control value). This change Appeared in the plasma fibrinogen concentration and HCT before significant changes, suggesting that the early acute myocardial ischemia abnormal increase in blood viscosity in addition to the impact of plasma fibrinogen and HCT, there may be some other rapid mechanisms of regulation have not been clarified. The increase of whole blood viscosity in ischemic area under local high blood shear rate (r = 230s ~ (-1)) was significantly higher than that of systemic circulation, which may be related to the accumulation of acidic metabolites in ischemic area, the increase of H ~ + concentration, Partial pressure reduction related.