近年来,国内外对前列腺素(简称PG)在胃肠粘膜的细胞保护作用做了许多工作,研究结果表明PG不但可以有效地对抗外来伤害性因子对胃肠粘膜的损伤,而且对肝、胰等脏器的实质性细胞也具有细胞保护作用,PG对胰腺内分泌细胞是否具有细胞保护作用,目前尚未见报道。本工作以四氧嘧啶(皮下注射)造成大鼠实验性糖尿病模型,观察了PGE_2对糖尿病发病过程的影响。结 In recent years, a lot of work has been done at home and abroad on the cytoprotective effect of prostaglandin (PG) on the gastrointestinal mucosa. The results of the study indicate that PG can not only effectively counteract the damage of external injury factors to the gastrointestinal mucosa, but also to the liver and pancreas. The substantial cells of other organs also have cytoprotective effects, and whether PG has cytoprotective effect on pancreatic endocrine cells has not yet been reported. In this study, alloxan (subcutaneous injection) was used to establish a model of experimental diabetes in rats, and the effect of PGE 2 on the pathogenesis of diabetes was observed. Knot