类恶性综合征(neuroleptic malignant syndro-me,NMS)首次描述于1968年。临床特点包括高热、运动不能、意识障碍、僵硬、植物性神经功能障碍及血清肌酸磷酸激酶增高。未经治疗,症状一般持续几天～几周,据估计其死亡率为20%。阻滞多巴胺受体的药物是最常见的原因。本文报告3例发生于停用左旋多巴的帕金森病。3例均无应用抗精神药物史,以 For the first time, neuroleptic malignant syndro-me (NMS) was described in 1968. Clinical features include hyperthermia, impotence, disturbance of consciousness, stiffness, autonomic nerve dysfunction and increased serum creatine phosphokinase. Without treatment, the symptoms usually last from days to weeks, with an estimated mortality rate of 20%. Drugs that block dopamine receptors are the most common cause. This article reports 3 cases of Parkinson’s disease in the disabled levodopa. No application of antipsychotic history in 3 cases