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目的 观察内皮素拮抗剂 ＢＱ－１２３对缺血再灌流后脑神经元损伤的保护作用。方法 采用Ｐｕｓｉｎｅｌｌｉ的四血管阻断法（４ＶＯ）制作大鼠全脑缺血再灌流动物模型。在再灌流后 ３０分钟给予ＢＱ－１２３（５０μｇ／１μｌ，ｉｃｖ）。结果 ＢＱ－１２３能增加缺血后海马ＣＡ１区神经元的存活数，行为实验表明 ＢＱ－１２３治疗后大鼠的学习了己忆能力有提高。结论 内皮素受休拮抗剂 ＢＱ－１２３对全脑缺血再灌流引起海马区神经元损伤有部分保护作用。
Objective To observe the protective effect of endothelin antagonist BQ-123 on neuronal damage after cerebral ischemia and reperfusion. Methods Pusinelli four-vessel occlusion (4VO) rat model of global cerebral ischemia and reperfusion was made. BQ-123 (50 μg / 1 μl, icv) was given 30 minutes after the reperfusion. Results BQ-123 increased the number of neurons in hippocampal CA1 area after ischemia, and the behavioral experiments showed that the learning ability and memory capacity of BQ-123 increased. Conclusion Endothelin antagonist BQ-123 may partly protect neurons in hippocampus induced by global cerebral ischemia / reperfusion.