自从人们要求我总结一下我对脆性部位和肿瘤断裂点的看法之后,我便开始围绕着这个题目进行考虑。过去我一直乐观地认为,染色体上的脆性部位——我十多年来的主要研究课题,是不会被列入那张不断加长的名单中去的,因为那张名单包含了从香烟到放射性物质这样一些与肿瘤形成有关的东西。而我对脆性部位则充满了偏爱。最初我有意识地试图把脆性部位与肿瘤细胞(CBP)染色体重排中观察到的非随机断裂点联系起来是在1983年我与Hecht夫妇一起休假时开始的。那时,Yunis发表了一些 Since people asked me to sum up my views on fragile parts and tumor rupture points, I began to consider this topic. In the past, I have been optimistic that the brittle parts of chromosomes, which I have studied for more than a decade, will not be included in the ever-increasing list, because the list contains everything from cigarettes to radioactivity. Substances such as those related to tumor formation. And I am full of preference for fragile parts. Initially I consciously attempted to associate the fragile site with non-random breakpoints observed in chromosome rearrangements in tumor cells (CBP) when I was on vacation with the Hecht couple in 1983. At that time, Yunis published some