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目的:探讨胱抑素C和同型半胱氨酸与早期糖尿病肾病的相关性。方法:我院90例疑诊2型糖尿病肾病患者,根据24小时尿微量白蛋白排泄率,将其分为A组(单纯糖尿病)、B组(糖尿病肾病早期)、C组(糖尿病肾病中晚期),每组各30例,检测和比较各组肾小球率过滤(GFR)、血清胱抑素C(Cys C)、血浆同型半胱氨酸(Hcy)、血肌酐(Scr)、尿素氮(BUN)水平。结果:同型半胱氨酸、胱抑素C水平与2型糖尿病患者GFR、Scr、BUN具有明显相关性,对于糖尿病肾病的早期诊断,具有较高灵敏度和特异性。结论:Hcy、Cys C可作为2型糖尿病肾病早期诊断的重要指标,值得临床推广。
Objective: To investigate the relationship between cystatin C, homocysteine and early diabetic nephropathy. Methods: Ninety patients with suspected type 2 diabetic nephropathy in our hospital were divided into group A (simple diabetes mellitus), group B (early diabetic nephropathy), group C (middle and late diabetic nephropathy) according to the urinary albumin excretion rate at 24 hours ), 30 cases in each group. GFR, Cys C, Hcy, Scr, urea nitrogen (BUN) level. Results: The levels of homocysteine and cystatin C were significantly correlated with GFR, Scr and BUN in patients with type 2 diabetes mellitus, with high sensitivity and specificity for the early diagnosis of diabetic nephropathy. Conclusion: Hcy and Cys C can be used as early diagnosis of type 2 diabetic nephropathy an important indicator, worthy of clinical promotion.