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1 凝血的初始阶段 在实验室认识经典的内源性凝血和外源性凝血途径已经有多年了,在正常的止血过程中,血管内的外源性凝血(组织因子)路径被认为在启动血液凝固中起主要作用。血循环中,Ⅶ因子大多以无活性的酶原形式存在。只有微量有活性的Ⅶa因子,不超过Ⅶ因子总量的百分之一。Ⅶa因子由于缺少辅助因子(组织因子TF)而最终被灭活。当血管受损后,Ⅶ因子特异性膜联
The initial stage of coagulation In the laboratory to understand the classic endogenous coagulation and extrinsic coagulation pathway for many years, during normal hemostasis, vascular extrinsic coagulation (tissue factor) pathway is considered in the start-up of blood Solidification plays a major role. In the blood circulation, most of the factor VII exists in the form of inactive zymogen. Only a small amount of active factor Ⅶ a, does not exceed 1% of the total factor Ⅶ. Factor VIIa is eventually inactivated due to the absence of cofactor (tissue factor TF). When the blood vessel is damaged, Ⅶ factor-specific membrane