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目的对粉尘螨的过敏原蛋白之一的der f 28的结构与性质进行生物信息方面的分析,为粉尘螨所导致的变态反应性疾病的诊断和治疗提供线索。方法通过对der f 28进行BLAST得到的相似序列进行构建进化树,同时对der f28的二级结构、亲水性区域、可塑性区域、抗原性区域进行分析。结果粉尘螨与其他微生物物种中的热休克蛋白70(HSP70)在进化上相似性不高。der f 28的主要抗原位点为24~39、93~103、150~163、202~205、244~281、414~434、450~484、551~605。Motif的预测表明der f 28具有热休克蛋白70家族的特征。其预测的三维结构基本能反应der f 28真实的空间构象。结论掌握der f 28结构和功能的的关系,对粉尘螨所引起的变态反应性疾病的诊断和治疗有临床意义。
OBJECTIVE: To analyze the structure and properties of der f 28, one of the allergens of dust mites, and provide clues for the diagnosis and treatment of allergic diseases caused by dust mite. Methods The phylogenetic tree was constructed by BLAST analysis of der f 28, and the secondary structure, hydrophilicity, plasticity and antigenicity of der f28 were also analyzed. Results Dust mite and other microbial species of heat shock protein 70 (HSP70) evolutionary similarity is not high. The major antigenic sites of der f 28 are 24-39,93-103,150-163,202-205,244-281,414-434,450-484,551-605. Motif’s predictions indicate that der f 28 has the characteristics of the heat shock protein 70 family. Its predicted three-dimensional structure can basically reflect the true spatial conformation of der f 28. Conclusion It is of clinical significance to grasp the relationship between the structure and function of der f 28 in the diagnosis and treatment of allergic diseases caused by dust mites.