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目的:探讨糖皮质激素与茶碱对哮喘患者嗜酸性细胞阳离子蛋白(ECP)的影响。方法:将54例轻、中度支气管哮喘患者随机分为两组,分别给予吸入皮质激素(A组)及吸入皮质激素配合茶碱治疗(B组)。疗程4周,监测治疗前后患者FEV1%及血清ECP的水平。结果:治疗后两组患者FEV1%均较治疗前明显提高(P<0.01),血清ECP水平较治疗前显著下降(P<0.01)。B组患者血清ECP水平的下降及FEV1%水平的提高,较A组明显,有显著性差异。结论:糖皮质激素与茶碱合用可以抑制嗜酸细胞的活性,降低哮喘患者血清ECP水平,改善通气功能,且可增强抗炎效果。
Objective: To investigate the effects of glucocorticoids and theophylline on eosinophil cationic protein (ECP) in asthmatic patients. Methods: Fifty-four patients with mild or moderate bronchial asthma were randomly divided into two groups. Patients were given inhaled corticosteroids (group A) and inhaled corticosteroids (group B) respectively. The course of treatment was 4 weeks, and the level of FEV1% and serum ECP were monitored before and after treatment. Results: After treatment, the FEV1% in both groups was significantly higher than that before treatment (P <0.01), and the serum ECP level was significantly lower than that before treatment (P <0.01). Serum ECP levels and the level of FEV1% increase in group B were significantly higher than that in group A, with significant difference. Conclusion: Combination of glucocorticoids and theophylline can inhibit the activity of eosinophils, reduce the level of serum ECP in asthmatic patients, improve the ventilatory function and enhance the anti-inflammatory effect.