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小分子核糖核酸(micro RNA,miRNA)的高度保守性以及稳定性使其在生命活动中不易被降解,发挥调节信使RNA转录后生成蛋白质的作用,以此影响细胞中能量生成、氧化还原、信号转导以及程序性死亡等生理活动,并在病理情况下使细胞功能失调。线粒体在细胞内三磷酸腺苷的生成、活性氧系统的产生及促凋亡物质的释放中起重要作用。MiRNA可以通过影响某些蛋白,如低氧诱导因子-α,硫酸亚铁集落蛋白2以及线粒体动力蛋白-1等调节线粒体的结构与功能,改变线粒体的活性。
The high degree of conservation and stability of small RNAs (miRNAs) makes them less likely to be degraded in life activities and plays a role in regulating the transcription of messenger RNAs to produce proteins, thereby affecting the energy production, redox signaling, Transduction and programmed death and other physiological activities, and under the pathological conditions of cell dysfunction. Mitochondria play an important role in the generation of intracellular adenosine triphosphate, the production of reactive oxygen species and the release of pro-apoptotic substances. MiRNA can change the structure and function of mitochondria by affecting certain proteins, such as hypoxia-inducible factor-α, ferrous sulfate, colloidal protein 2, and mitochondrial dynein-1 to change mitochondrial activity.