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目的:观察中西医结合治疗围绝经期功能性子宫出血的临床疗效。方法:选择150例围绝经期功能性子宫出血患者,按照随机数字表法分为西医组和中西医结合组,每组75例。西医组行诊刮术配合去氧孕烯炔雌醇片口服治疗,中西医结合组在对照组治疗基础上加服固冲汤。治疗后比较2组临床疗效,观察治疗前后血清性激素水平及子宫内膜厚度的变化,监测治疗过程中出现的不良反应。结果:西医组和中西医结合组的治疗总有效率分别为82.67%和93.33%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组血清促卵泡生成素(FSH)、促黄体生成素(LH)、雌二醇(E_2)水平均较治疗前降低(P<0.05),中西医结合组的以上3项血清性激素指标水平均较西医组下降更明显(P<0.05)。治疗后,2组子宫内膜厚度比较,差异无统计学意义(P>0.05)。西医组不良反应发生率16.0%;中西医结合组不良反应发生率18.7%,2组比较,差异无统计学意义(P>0.05)。结论:在诊刮术合去氧孕烯炔雌醇片治疗基础上加用固冲汤治疗围绝经期功能性子宫出血,治疗效果显著提高,血清性激素水平明显改善,不良反应人数未增加。
Objective: To observe the clinical efficacy of integrated traditional Chinese and western medicine in treating peri-menopausal dysfunctional uterine bleeding. Methods: One hundred and fifty patients with functional uterine bleeding during perimenopausal period were selected and randomly divided into western medicine group and integrated traditional Chinese and western medicine group with 75 cases in each group. Western medicine group curettage with deoxynivalenol estradiol tablets oral treatment, Integrative Medicine group in the control group based on the treatment plus solid soup. After treatment, the clinical efficacy was compared between the two groups. Changes of serum sex hormone levels and endometrial thickness were observed before and after treatment. Adverse reactions were observed during the treatment. Results: The total effective rates of the Western medicine group and the integrated traditional Chinese and Western medicine group were 82.67% and 93.33%, respectively. There was significant difference between the two groups (P <0.05). After treatment, the levels of serum FSH, LH and E2 in the two groups were significantly lower than those before treatment (P <0.05). The level of serum FSH, Indicator levels were significantly lower than those in Western medicine group (P <0.05). After treatment, there was no significant difference in the thickness of endometrium between the two groups (P> 0.05). The incidence of adverse reactions in the Western medicine group was 16.0%. The incidence of adverse reactions in the Integrative Medicine group was 18.7%. There was no significant difference between the two groups (P> 0.05). Conclusion: The treatment of deciduas combined with ethinyl estradiol desogestrel plus solid-based decoction on the basis of treatment of functional uterine bleeding during peri-menopausal period, the treatment effect was significantly improved serum levels of sex hormones significantly improved the number of adverse reactions did not increase.