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对107例重型病毒性肝炎与肝炎病原学的关系进行了分析，结果显示：亚重肝病人HBV复制指标HBeAg、HBcAbIgM及HBV－DNA阳性率高于慢重肝，而慢重肝的HbeAb阳性率（54．2％）明显高于亚重肝（27．8％）。此外，还发现51．4％的重肝病人由单纯HBV感染引起，HBV合并HCV感染的重肝病人仅为23．4％。但是HBV与HCV重叠感染的重肝病人的病死率（52．0％）明显高于单纯HBV感染（29．1％）。以上结果提示：慢重肝可能主要由抗HBe阳性的HBV病毒株所引起。HBV与HCV的重叠感染能加重病人病情，增加病死率。
The relationship between 107 cases of severe viral hepatitis and hepatitis etiology was analyzed. The results showed that the positive rates of HBeAg, HBcAbIgM and HBV-DNA of HBV replication in sub-severe hepatitis were higher than those in chronic severe liver, while the positive rates of HbeAb (54.2%) was significantly higher than the sub-heavy liver (27.8%). In addition, it was also found that 51.4% of patients with severe hepatitis were caused by simple HBV infection, with only 23.4% of patients with severe hepatitis with HCV infection. However, the case-fatality rate (52.0%) in patients with severe hepatitis complicated with HCV infection was significantly higher than that in HBV patients (29.1%). The above results suggest that chronic severe hepatitis may be mainly caused by anti-HBe-positive HBV strains. Over-infection of HBV and HCV can aggravate the patient’s condition and increase the mortality.