罗非昔布是一种新型非甾体抗炎药,是环氧化酶抑制剂的代表性药物,服用罗非昔布会增加患心脏病或中风的危险.虽然罗非昔布曾由于心血管安全风险而撤市,但其优异的镇痛抗炎活性仍然具有很大的研究价值和广阔的应用前景,因此以罗非昔布为先导寻找具有更高药理活性或更低毒副作用的罗非昔布衍生物一度成为研究热点.综述了罗非昔布及其衍生物的研究进展,包括罗非昔布合成工艺的研究,罗非昔布衍生物的合成. Rofecoxib is a novel non-steroidal anti-inflammatory drug, a representative drug for cyclooxygenase inhibitors, and increases the risk of heart disease or stroke when taking rofecoxib. Vascular safety risks and the withdrawal of the market, but its excellent analgesic and anti-inflammatory activity still has great research value and broad application prospects, so the use of rofecoxib as a pilot to find more pharmacologically active or less toxic side effects of Luo The recent advances in the research of rofecoxib and its derivatives include the synthesis of rofecoxib, the synthesis of rofecoxib derivatives.