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急性心肌梗塞(以下简称AMI)的早期诊断对本病及时有效的治疗是十分重要的。虽然根据临床病状,常规心电图及血清酶学检查对大部份AMI患者能做出确切诊断,但对一些早期不典型病例的诊断与鉴别诊断尚需要一种更为灵敏可靠的检查方法。十多年来对AMI患者尿和血中肌红蛋白(以下称SMb)用不同方法进行测定有过不少报导。但1975年Stone建立人SMb放射免疫测定法,因其敏感性极高可测出毫微克/毫升(ng/ml)水平,加之操作方法的不断改进,使其得以实际应用于临床作为对AMI之早期辅助诊断,但亦有不少作者对此方法在本病早期诊断中的价值提出质疑。1981年以来我们应用人SMb放免药盒主要对冠心病AMI及心绞痛病人进行了较系统的观察。现将我们观测的结果和体会简要报告如下:
Acute myocardial infarction (hereinafter referred to as AMI) early diagnosis of the disease timely and effective treatment is very important. Although based on clinical symptoms, conventional electrocardiogram and serum enzymatic examination can make the exact diagnosis of most patients with AMI, but the diagnosis and differential diagnosis of some early atypical cases still need a more sensitive and reliable test method. More than a decade of AMI patients urine and blood in the determination of myoglobin (hereinafter referred to as SMb) using different methods have been reported. However, since Stone established a human SMb radioimmunoassay in 1975, it is capable of detecting ng / ml levels because of its high sensitivity, combined with continuous improvements in its methods of operation, allowing it to be used clinically as an alternative to AMI Early diagnosis, but there are many authors questioned the value of this method in the early diagnosis of this disease. Since 1981, we applied human SMb radiopharmaceutical kit mainly for coronary heart disease AMI and angina patients were more systematic observation. Now we observe the results and experience brief report as follows: