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目的探讨我国锑及其化合物的职业接触生物限值。方法选择广西地区一家锑白粉(Sb2O3)加工厂和一家锑矿冶炼厂的办公室行政人员33名作为对照组;83名工作场所工人作为接触组,采集并检测空气样品和生物样品(尿样),对检测结果进行统计分析。结果两厂均存在接触组空气中锑及其化合物浓度高于对照组,差异有统计学意义(P<0.01);两厂均存在接触组班末尿锑浓度高于对照组的情况,差异有统计学意义(P<0.01);全体调查对象接触空气中锑及其化合物的浓度与班末尿锑浓度间存在良好的相关关系(n=116,r>0.5);班末尿锑浓度经对数正态性转换后与空气中锑及其化合物浓度做直线回归分析,把职业接触限值(PC-TWA:0.5mg/m3)代入回归方程,推算出班末尿锑浓度为60或85μg/g肌酐。结论建议锑及其化合物的职业接触生物限值为班末尿锑60或85μg/g肌酐。
Objective To investigate the occupational exposure limits of antimony and its compounds in our country. Methods A total of 33 office administrative staff of an antimony white powder (Sb2O3) processing plant and an antimony ore smelter in Guangxi were selected as the control group. 83 workers in the workplace were used as the exposure group to collect and test air samples and biological samples (urine samples) The test results for statistical analysis. Results The concentrations of antimony and its compounds in air were higher in the two plants than in the control group (P <0.01). There was a higher concentration of antimony in the two groups than the control group (P <0.01). There was a good correlation between concentration of antimony and its compounds in the air and total urine antimony concentration (n = 116, r> 0.5) After normal conversion, the concentrations of antimony and its compounds in the air were linear regression analysis, and the occupational exposure limit (PC-TWA: 0.5mg / m3) was substituted into the regression equation to calculate the concentration of antimony in the end of the month as 60 or 85μg / g creatinine. Conclusion It is recommended that the bioassay limit of exposure to antimony and its compounds be 60 or 85 μg / g creatinine at the end of the study.