系统性红斑狼疮(Systemic lupus erythematosus)在我国并不少见,发病率虽尚乏具体统计数字,但近年来各地印象都有增加的趋势。本病累及人体多数器官和组织,伴以多种血液学和血清学上的变化,病情复杂多样。近年国内外对该病的研究日渐重视,文献报导亦渐增多,使该病的诊断、治疗及免疫学研究有了很大进展。现将20年来广州市第一人民医院及广州医学院附属第一医院住院SLE203例作一报导,并结合文献,着重对该病的诊断问题进行讨论。 Systemic lupus erythematosus is not uncommon in our country. Although the incidence rate is still lacking of specific statistics, there is an increasing trend in recent years. This disease affects the body most organs and tissues, with a variety of hematological and serological changes, the condition is complex and diverse. In recent years, more and more attention has been paid to the research of this disease both at home and abroad, and the reports of the literature have also been increasing. The research on diagnosis, treatment and immunology of the disease has made great progress. Now 20 years Guangzhou First People’s Hospital and the First Affiliated Hospital of Guangzhou Medical College Hospital SLE203 cases for a report, combined with the literature, focusing on the diagnosis of the disease are discussed.