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人附睾蛋白4(human epididymis protein 4,HE4)是新近提出的卵巢恶性肿瘤标记物,有研究显示,卵巢恶性肿瘤组织中HE4为高表达,而在癌旁组织、良性肿瘤和正常组织中水平较低。卵巢浆液性癌中HE4基因表达的水平高于其他恶性肿瘤,HE4可能参与了细胞周期的调控,促进卵巢癌迁移和入侵。研究表明,HE4是一个潜在的有效的卵巢肿瘤标记物,HE4可能比CA125更具有高效性。而且,HE4与肿瘤的病理分类、转移、预后均有一定关系。检测HE4可能对卵巢恶性肿瘤的诊断、病情和疗效的监测有一定价值。
Human epididymis protein 4 (HE4) is a recently proposed marker of ovarian malignancy. Studies have shown that HE4 is overexpressed in ovarian cancer tissues, while in paracancer tissues, benign tumors and normal tissues low. HE4 gene expression in ovarian serous carcinoma is higher than other malignant tumors, HE4 may be involved in the regulation of the cell cycle and promote ovarian cancer migration and invasion. Studies have shown that HE4 is a potentially effective ovarian tumor marker and that HE4 may be more potent than CA125. Moreover, HE4 and tumor pathological classification, metastasis, prognosis have a certain relationship. Detection of HE4 may be valuable in the diagnosis of ovarian cancer, the monitoring of disease and efficacy.