论文部分内容阅读
目的探讨青年亚临床甲减患者与早期AS的关系,评价患者的认知功能,为早期预测和防治亚临床甲减引起的认知功能损害提供依据。方法采肘部静脉血3 ml离心分离血清进行指标的检测。TSH、FT3、FT4采用电学发光法检测,hs-CPR测定采用全自动生化仪。认知功能检测采用中文版蒙特利尔认知评估量表(Mo CA)检测。结果采用Mo CA评价患者的认知功能,结果显示轻度组无明显认知功能障碍,至中度到重度认知功能障碍越明显。血清hs-CPR水平与TSH呈正相关,与认知障碍呈正相关。结论对于青年亚临床甲减患者应提高其认知功能损害的警惕性。hs-CPR反映体内的急性炎症对动脉粥样硬化严重程度有预测作用。
Objective To investigate the relationship between young subclinical hypothyroidism and early AS and to evaluate the cognitive function of patients so as to provide evidence for early prediction and prevention of cognitive impairment caused by subclinical hypothyroidism. Methods 3 ml elbow venous blood serum was centrifuged to detect the index. TSH, FT3, FT4 using the electrical luminescence detection, hs-CPR measurement using automatic biochemical analyzer. Cognitive function tests using the Chinese version of Montreal Cognitive Assessment Scale (MoCA) test. Results Using Mo CA to evaluate the cognitive function of patients, the results showed no significant cognitive impairment in mild group, and the more obvious to moderate to severe cognitive impairment. Serum hs-CPR levels were positively correlated with TSH and positively correlated with cognitive impairment. Conclusion For young patients with subclinical hypothyroidism should be alert to enhance their cognitive impairment. hs-CPR reflects the acute inflammation in the body to predict the severity of atherosclerosis.