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目的探讨聚乙烯醇微粒(PVA)联合碘化油栓塞化疗治疗肝细胞癌(HCC)的中远期疗效。方法将101例HCC患者随机分为单纯碘化油栓塞组(单纯组)44例和PVA微粒加碘化油联合栓塞组(联合组)57例,随访评价2年疗效。结果联合组平均治疗次数3.11±1.06次,少于单纯组4.25±1.42次,差异有统计学意义(t=-4.45,P=0.001)。随访12、24个月时联合组肝癌瘤体缩小总有效率均高于单纯组,差异有统计学意义(Z=-5.455,P=0.001;Z=-4.254,P=0.001)。结论 PVA微粒联合碘化油栓塞化疗治疗中晚期肝癌中远期疗效可靠,适于推广应用。
Objective To investigate the long-term effect of polyvinyl alcohol particles (PVA) combined with iodized oil embolization chemotherapy in the treatment of hepatocellular carcinoma (HCC). Methods A total of 101 patients with HCC were randomly divided into simple iodized oil embolization group (simple group) 44 cases and PVA particles plus iodized oil combined embolization group (combined group) 57 cases were followed up for 2 years. Results The average number of treatment in the combined group was 3.11 ± 1.06 times, less than 4.25 ± 1.42 in the simple group, the difference was statistically significant (t = -4.45, P = 0.001). At 12 and 24 months follow-up, the total effective rate of hepatocellular carcinoma in the combined group was significantly higher than that in the simple group (Z = -5.455, P = 0.001; Z = -4.254, P = 0.001). Conclusion PVA particles combined with iodized oil embolization chemotherapy in the treatment of advanced liver cancer in the long-term reliable, suitable for the promotion and application.